Pan-Resistome Insights into the Multidrug Resistance of Acinetobacter baumannii

Acinetobacter baumannii is an important Gram-negative opportunistic pathogen that responsible for many nosocomial infections. This etiologic agent has acquired, over the years, multiple mechanisms of resistance to a wide range antimicrobials and ability survive in different environments. In this context, our study aims elucidate resistome from A. strains based on phylogenetic, phylogenomic, comparative genomics analyses. silico analysis complete genomes was carried out identify genes involved phylogenetic relationships grouping sequence type. The presence genomic islands containing most gene repertoire indicated high plasticity, which probably enabled acquisition formation robust resistome. displayed open pan-genome revealed still constant genetic permutation among their strains. Furthermore, suggest specific profile within species throughout its evolutionary history. Moreover, current performed screening characterization main present resistome, can be used applied research develop new therapeutic methods control bacterial pathogen.